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Low back pain is the leading cause of disability worldwide and becomes increasingly common as human bodies age. Currently, more than 40 percent of low back pain patients are prescribed opioids at some point. Researchers at 51��Ʒ��Ƶ want to bring that number down.

“You would have to be living under a rock to not know we have an opioid crisis in the United States,” said , an associate professor in the 51��Ʒ��Ƶ’s School of Health and Rehabilitation Sciences. “Some people are extremely susceptible and can show dependency after just a few doses. What’s sad is that some people think this crisis is just poor, uneducated people. It’s not.”

To figure out ways to decrease prescriptions and treat pain appropriately, Schneider and colleagues at 51��Ʒ��Ƶ are part of a five-year, $11.2 million study funded by the National Institutes of Health that will test non-drug approaches to treating and preventing chronic low back pain.

Schneider, who teaches in the Department of Physical Therapy and the Clinical and Translational Science Institute, will serve as a co-principal investigator for a large multicenter clinical trial examining the effectiveness of spinal manipulation and supported self-management, compared to usual medical care.

In Pennsylvania alone, 4,642 drug-related overdose deaths were reported in 2016 by coroners and medical examiners, an increase of 37 percent from 2015, according to a joint report by the Drug Enforcement Agency’s Philadelphia Division and the 51��Ʒ��Ƶ.

“For cancer pain and post-operative care, people need opioids because they’re in very serious pain. But it’s surprising how often opioids are prescribed for acute back pain,” Schneider said.

51��Ʒ��Ƶ’s role in the study is to be a physical therapy site, while the University of Minnesota will be a chiropractic site and the University of Washington will assume a data management role. A total of 1,180 patients will take part in the study, with enrollment beginning next spring. Schneider said about 650 patients will be treated at the 51��Ʒ��Ƶsburgh site.

The researchers will compare spinal manipulation and supported self-management to usual medical care, which includes prescription medications for the care of acute lower back pain in adult patients at increased risk of becoming chronic.

Supported self-management includes self-care strategies that address the biological, psychological and social aspects of back pain through the use of behavioral and coping strategies, mind-body approaches, lifestyle advice and pain education.

The hope is that, by investigating the sources of pain, doctors can treat new episodes of back pain without prescriptions and intervene before back pain becomes a long-term problem.

“What we’re looking at is how this will affect opioid use, and that specific research question has not been looked at previously,” Schneider said. “We also want to look at whether or not we can prevent an acute episode of back pain from turning chronic.”

Non-medicinal methods of treating back pain have been gaining support in recent years.

from the American College of Physicians state that these nonmedicinal methods should be the first option for treating back pain. If medication is required for pain management, the guidelines state that nonsteroidal medicines should be prescribed. Opioids are considered to be a last-resort option. The Centers for Disease Control and Prevention also published a in 2016 acknowledging the risk of prescribing opioids to patients experiencing chronic pain.

“For the first time, we’re seeing things like spinal manipulation, yoga, tai chi and all sorts of non-pharmacological treatments previously considered quackery or pseudoscience have evidence that show they can work,” Schneider said. “And they certainly don’t have the side effects of medication. But it’s going to take a while for the average American and American doctor to be recommending these treatments.”

Other 51��Ʒ��Ƶ researchers involved in the study include Anthony Delitto, co-principal investigator for the Clinical Coordinating Center and dean of the School of Health and Rehabilitation Sciences; Carol Greco, associate professor of psychiatry and rehabilitation science and technology; Natalia Morone, associate professor of medicine and clinical and translational science; and Joel Stevans, assistant professor in the Department of Physical Therapy.

Other universities involved in the study include Oregon Health and Sciences University, Duke University and the University of North Texas.

Drug take back event to be held at 51��Ʒ��Ƶ on Oct. 26

While simply tossing old prescriptions in the garbage or flushing them down the toilet may seem like an easy option, there is a much safer way to dispose of these unwanted medications.

The 51��Ʒ��Ƶ’s School of Pharmacy invites the public to dispose of their unwanted medication at its next Drug Take Back Day on Thursday, Oct. 26.

From 9 a.m. to 3 p.m., people can take the following items to the University Pharmacy in Mark A. Nordenberg Hall: prescription and over-the-counter medications, vitamins, supplements, pet medications, non-leaking liquids, creams, gels and ointments.

Experts say take-back events like these are important in avoiding possible drug abuse, as addiction and dependency usually begins with prescription drugs sanctioned by physicians.

“My thought as a pharmacy student is that pharmacists should be doing more,” said Abigail Elmes, a third-year PharmD student and coordinator for the Drug Take Back Day, which occurs each semester. “I work as an intern at a retail pharmacy and get questions all time about how to get rid of medications, whether it's opioids or other ones.”

People who cannot make 51��Ʒ��Ƶ’s Drug Take Back Day can also take their unwanted drugs to their local police station.

The following items will not be accepted: needles and syringes, diabetic test strips, EpiPens and other injectables, inhalers, IV bags, thermometers and chemo medications.

Those attending the take-back event will have an opportunity to observe a simulated opioid overdose and reversal with naloxone, also known as Narcan. Information about local, state and national resources for addiction treatment will be available at the event.

The School of Pharmacy, along with 51��Ʒ��Ƶ Generation Rx, has hosted take back-days every semester since spring 2015. An average of 200 pounds of drugs are taken per event, with about 275 pounds of drugs taken back at the .

The event is sponsored by Student Affairs, 51��Ʒ��Ƶ Police and the Allegheny County District Attorney.